The OPRA trial was a prospective, randomized, phase II trial published in 2022. We provided a step-by-step practical review of the WW approach. Clinicians willing to adopt the WW strategy in their routine practice should assimilate the detailed approach. In this article, we summarized the main clinical results of the WW approach. Growing evidence has indicated that the WW approach was a safe and effective option in patients who achieved excellent tumor response after neoadjuvant treatment. In the WW approach, patients with locally advanced rectal cancer who achieve excellent clinical response after neoadjuvant treatment undergo active surveillance rather than rectal surgery. The watch-and-wait (WW) approach is a noninvasive therapeutic alternative for organ preservation and avoiding operative morbidity. Accordingly, there has been a demand for omitting surgical resection in these patients. The excellent oncologic outcomes in patients who achieved pathologic complete response (CR) after neoadjuvant treatment questioned the need for radical resection surgery. In addition, patients with very low tumors undergo abdominoperineal resection, which results in permanent colostomy. ![]() ![]() Rectal surgery is associated with significant morbidity, such as poor body image and gastrointestinal, micturition, and sexual problems. However, functional outcomes and quality of life after radical resection remain suboptimal. Total mesorectal excision has been the mainstay of treatment of locally advanced rectal cancer. Neoadjuvant therapy-such as long-course chemoradiotherapy and short-course radiotherapy, surgical resection, and adjuvant chemotherapy-are conventional treatments of locally advanced rectal cancer.
0 Comments
![]() Data defense is about minimizing downside risk. ![]() Few if any data-management frameworks are as business-focused as ours: It not only promotes the efficient use of data and allocation of resources but also helps companies design their data-management activities to support their overall strategy.ĭata defense and offense are differentiated by distinct business objectives and the activities designed to address them. Although information on enterprise data management is abundant, much of it is technical and focused on governance, best practices, tools, and the like. Unlike other approaches we’ve seen, ours requires companies to make considered trade-offs between “defensive” and “offensive” uses of data and between control and flexibility in its use, as we describe below. Our framework addresses two key issues: It helps companies clarify the primary purpose of their data, and it guides them in strategic data management. As such, they’re not just the concern of the CIO and the CDO ensuring smart data management is the responsibility of all C-suite executives, starting with the CEO. The “plumbing” aspects of data management may not be as sexy as the predictive models and colorful dashboards they produce, but they’re vital to high performance. The strategy enables superior data management and analytics-essential capabilities that support managerial decision making and ultimately enhance financial performance. The framework draws on our implementation experience at the global insurer AIG (where DalleMule is the CDO) and our study of half a dozen other large companies where its elements have been applied. In this article we describe a new framework for building a robust data strategy that can be applied across industries and levels of data maturity. Indeed, without such strategic management many companies struggle to protect and leverage their data-and CDOs’ tenures are often difficult and short (just 2.4 years on average, according to Gartner). Having a CDO and a data-management function is a start, but neither can be fully effective in the absence of a coherent strategy for organizing, governing, analyzing, and deploying an organization’s information assets. Data breaches are common, rogue data sets propagate in silos, and companies’ data technology often isn’t up to the demands put on it. More than 70% of employees have access to data they should not, and 80% of analysts’ time is spent simply discovering and preparing data. Cross-industry studies show that on average, less than half of an organization’s structured data is actively used in making decisions-and less than 1% of its unstructured data is analyzed or used at all. But even with the emergence of data-management functions and chief data officers (CDOs), most companies remain badly behind the curve. More than ever, the ability to manage torrents of data is critical to a company’s success. Regardless of its industry, a company’s data strategy is rarely static typically, a chief data officer is in charge of ensuring that it dynamically adjusts as competitive pressures and overall corporate strategy shift. The SolutionĬompanies need a coherent strategy that strikes the proper balance between two types of data management: defensive, such as security and governance, and offensive, such as predictive analytics. But data theft is common, flawed or duplicate data sets exist within organizations, and IT is often behind the curve. To remain competitive, companies must wisely manage quantities of data. Using this approach, managers can design their data-management activities to support their company’s overall strategy. Data offense focuses on supporting business objectives such as increasing revenue, profitability, and customer satisfaction. The framework will help managers clarify the primary purpose of their data, whether “defensive” or “offensive.” Data defense is about minimizing downside risk: ensuring compliance with regulations, using analytics to detect and limit fraud, and building systems to prevent theft. In this article, the authors describe a framework for building a robust data strategy that can be applied across industries and levels of data maturity. More than 70% of employees have access to data they should not. Although the ability to manage torrents of data has become crucial to companies’ success, most organizations remain badly behind the curve. However, there exists little empirical evidence on how food resources are shared within this guild, and none for direct competition for food between megaherbivores. Consequently, they are considered a separate trophic guild that structures the food niches of coexisting large herbivores. The research was approved by the University of Bristol Animal Welfare and Ethical Review Body (AWERB) (reference number: UIN/21/049) and the Namibian National Commission on Research, Science and Technology (permit number: RPIV01042026).In African large herbivore assemblages, megaherbivores dominate the biomass and utilise the greatest share of available resources. Sharing of data will also allow for larger studies across wider areas on other aspects such as rhino behaviour, habitat use and management practices. It is particularly important for future studies to collate data from as many reserves, conservancies and national parks across as many countries as possible, so a larger analysis not only on the effects of dehorning but also its effectiveness as an anti-poaching deterrent can be conducted. "Our study found there were no statistically significant differences in any of the measures of population productivity evaluated between dehorned and horned rhinos, which is reassuring for the use of dehorning as an anti-poaching deterrent in black rhinos."ĭue to the small sample size, more research is needed following the findings. Lucy Chimes, former MSc student from the University of Bristol Veterinary School, said: "In an ideal world no one would want to remove arguably one of the most iconic features of a rhino, its horn, but unfortunately this is not an ideal world and relentless poaching has forced many reserves to resort to dehorning. Previously it has been suggested that dehorning could have some effect on rhino behaviour and biology, either through the consequences of not having a horn or the dehorning process itself, where the animal has to be sedated. It is vital that anti-poaching measures themselves do not compromise the population growth of rhinos. The study found no evidence that dehorning has a negative impact on black rhinos, which is encouraging for the continued use of dehorning as an anti-poaching technique in this species. The measures investigated included: age of females at the birth of their first calf (age at first reproduction or AFR) average time between the birth of calves for each female (inter-calving interval) birth sex ratios, calf survival, life span and cause of death Three of the populations had undergone some level of dehorning at least once while one of the populations had never been dehorned. ![]() ![]() The study aimed to build on existing knowledge of population productivity between dehorned and horned individuals in four sub-populations of black rhino (of the sub-species Diceros bicornis bicornis) in Namibia. Many reserves across a number of African countries, including Namibia, South Africa, and Zimbabwe, now dehorn their rhinos in an attempt to reduce poaching but few studies have looked at the impacts of dehorning, particularly in black rhinos. The black rhino is critically endangered, with poaching one of several threats to the species' survival. ![]() It therefore might well form an immediate entrance and exit to the palace while the grand Gate of Justice served as the entrance of state to the fortress. The antiquaries of Granada pronounce it the entrance to that quarter of the royal residence where the king's bodyguards were stationed. ![]() According to Swinburne the traveller, it was originally the great gate of entrance. ![]() ![]() It is famous in the neighborhood as the scene of strange apparitions and Moorish enchantments. The gateway is in the centre of what was once an immense pile, called the Tower of the Seven Floors (la Torre de los Siete Suelos). There was a mystery about it, and it had never been opened within the memory of the oldest inhabitant. I inquired for some time in vain for such a portal at length my humble attendant, Mateo Ximenes, said it must be one closed up with stones, which, according to what he had heard from his father and grandfather, was the gateway by which King Chico had left the fortress. Consintio en allo el Rey Fernando, y des de aquel tiempo no solamente no se abrio la puerta sino tambien se construyo junto a ella fuerte bastion.- MORERI'S Historical Dictionary. Pidio esta principe como por merced, y en memoria de tan importante conquista, al que queda**e siempre cerrada esta puerta. Fernando, y le entrego la ciudad con el castillo. * Ay una puerta en la Alhambra por la qual salio Chico Rey de los Moros, quando si rindio prisionero al Rey de Espana D. His prayer, according to ancient chronicles, was complied with, through the sympathy of isabella, and the gate was walled up.* With the melancholy caprice of a broken spirit, or perhaps with some superstitious feeling, he requested of the Catholic monarchs that no one afterwards might be permitted to pa** through it. I next sought the gate by which Boabdil made his last exit from the Alhambra, when about to surrender his capital and kingdom. As I paced the gallery, my imagination pictured the anxious queen leaning over the parapet listening, with the throbbings of a mother's heart, to the last echoes of the horses' hoofs as her son scoured along the narrow valley of the Darro. From this gallery, it is presumed, the queen lowered her son with the scarfs of herself and her female attendants during the darkness of the night to the hillside, where some of his faithful adherents waited with fleet steeds to bear him to the mountains.īetween three and four hundred years have elapsed, yet this scene of the drama remains almost unchanged. A narrow stone gallery, with a low parapet, extends along three sides of the tower just below the windows, but at a considerable height from the ground. The external walls of these chambers are of prodigious thickness, pierced with small windows secured by iron bars. In the Tower of Comares, immediately under the Hall of Amba**adors, are two vaulted rooms, separated by a narrow pa**age these are said to have been the prisons of himself and his mother, the virtuous Ayxa la Horra indeed, no other part of the tower would have served for the purpose. While my mind was still warm with the subject of the unfortunate Boabdil, I set forth to trace the mementos of him still existing in this scene of his sovereignty and misfortunes. Washington Irving - Mementos of Boabdil lyrics The Company continues to exploit new global market opportunities independently and with partners. Nanalysis' devices are used in many industries (oil and gas, chemical, mining, pharma, biotech, flavor and fragrances, agrochemicals, law enforcement, and more) as well as numerous government and university research labs around the world. In 2020 Nanalysis announced the launch of its100MHz device, the most powerful and most advanced compact NMR device ever brought to market. The company has followed-up that initial offering with new products and continues to have a strong innovation pipeline. The NMReady-60™ was the first full-feature portable NMR spectrometer in a single compact enclosure requiring no liquid helium or any other cryogens. The Company develops and manufactures portable Nuclear Magnetic Resonance (NMR) spectrometers or analyzers for laboratory and industrial markets. Nanalysis' business is what we term "MRI and NMR for industry". News Provided by ACCESSWIRE via QuoteMediaĪbout Nanalysis Scientific Corp. View additional multimedia and more ESG storytelling from Medtronic on .Ĭontact Info: Spokesperson: Medtronic Website: Email: Medtronic View source version on : See our employees in action and learn more about our impact here. They have stayed in touch and continue to deepen their efforts with Glasswing International - empowering communities and transforming lives. "But now with the help of a strong community, I don't feel alone even if the goal feels unattainable."Įven after the school makeovers wrapped up, the new relationship with Glasswing International, the local schools, and employees was just the beginning. "They want to make change and have local knowledge, plus there is a real community pride when you have a school that not only looks good but has the resources for the students to thrive."Īnd with the support of the Medtronic Foundation, which funded the initiative, Abzueta and her committee of local employee volunteers feel like they can do even more. "We empower people to have that agency in their own community to drive change," he said. As Loyka puts it, "Who knows the community better than the community?" Glasswing was founded to get community members involved in volunteerism. country director for Glasswing International. "That's the impact of a project like this," said Mark Loyka, U.S. Studies show that a safe, healthy learning environment promotes attendance and helps students thrive socially, emotionally, and academically.Īnd that matters in areas that have historically been under-funded, where kids can end up dropping out of school to find - sometimes dangerous - ways to support their families. Revitalizing schools is about more than beautification. They painted, built - and filled - bookshelves, and planted trees. A majority of volunteers were manufacturing employees. In efforts to engage manufacturing employees in the DR and Mexico, the Medtronic Foundation reached out with an opportunity with Glasswing International, an organization that addresses the root causes and consequences of poverty through education and health programs that empower youth and communities.įor Abzueta, the goal was to make a local school feel like a safe and inviting place that could also function as a community center for families - many of whom work at Medtronic.Īlmost 200 employees in Mexico and the DR came together to give three schools a makeover in three days. The small - but mighty - team continued to take on new projects, but found itself hitting barriers when trying to engage a majority of the local workforce. With each effort, the team logged their hours with the Medtronic Foundation. ![]() To help, Abzueta joined a committee and led volunteers to do more. When she joined Medtronic as an engineer in 2017, her colleagues in the DR often volunteered in the community, but there wasn't a formal process for getting involved. When Olwi Abzueta learned a school in her community in the Dominican Republic (DR) needed help, she knew she couldn't turn down the opportunity to make a difference Copper Prices Could See "Astronomical Rise" as Supply Concerns Increase.10 Largest Producers of Gold by Country. ![]() With the steps in this article, you’ll be able to access your eBay purchase history for up to three years in the past and even further back with other options like online wallets and email. Whether to return an item, settle a dispute, or contact a seller, being able to access old eBay purchase history can be a lifesaver sometimes. If you have any problems when signing in, check this support page. Use the same username or email address related to that account and reset your password. If the purchase history you want to access is stored in an old eBay account, you can reactivate it by logging in. You’ll be able to scroll through a list of all items you sold in the last 60 days. If you’re a seller and want to view your eBay sales history, go to the ‘ Selling’ tab in My eBay and click on the ‘ Sold’ option. Just head to the Purchase History page, select the drop-down menu next to any item you want to hide, and click on ‘ Hide Item.’ How to Recover eBay Sales History? You can’t delete items in the purchase history, but you can hide them instead. ![]() How to Delete Items in eBay Purchase History? Here are some common questions related to recovering your old eBay purchases history. It could take a few days until the data is ready to be downloaded. It’ll include all the data eBay has on you ever since you signed up for an account. ORDER DATE ORDER NUMBER SOLD BY ORDER TOTAL 20-05963-30581 fancystore-2017 (1. To do this, go to the Account tab in My eBay and click on ‘ Request your eBay data’ under Personal Info. Returns and canceled orders Watchlist My eBay. Request Data from eBayĪs a final option, you can also request data directly from eBay too. If you can’t find the item you’re looking for on your Purchase History page, try scouring through your inbox for the email concerning that item. Like any other e-commerce platform, eBay notifies you by email whenever a purchase is made. PayPal easily lets you download a statement with transaction activity for up to the past seven years. If you pay for your eBay purchases with PayPal or other online wallets, you can access a record of those transactions from those platforms. If you want to view your purchase history that stretches past three years or can’t find the item you’re looking for, here are three useful alternative methods. Three Options to View Older eBay Purchase History In the next section, we will discuss a few additional methods you can try. If you couldn’t find what you were looking for by following these steps, don’t worry. The item was purchased from a different account or was a Guest purchase.But what if you couldn’t find the item you were looking for? There are three main reasons for this. If you want to download your entire purchase history, you can use a Chrome extension like this to do so. Step 3: For further options like contacting the seller or returning an item, you can click on the More Actions drop-down menu on the right side of each item. ‘ Recent’ will show you purchases made within the last 60 days, and ‘ Archived’ will go as far back as three years! You can narrow down the item you’re looking for by using the drop-down menu and specifying a time frame. Balance Forecast – Forecast your future account balances to help prevent insufficient funds.Keep a Budget – Set a budget for all your expenses and keep track of your progress.Use reports to make tax time easier and less stressful. Reports and Charts – Generate detailed reports and charts and see exactly where your money is going.Bill & Deposit Reminder – Set bill reminders and see all your upcoming payments so you never forget to pay a bill again.Balance your checkbook and keep your accounts in order. Detail of Spending – Categorize your spending & income.and see all your account balances in one place. Track Your Accounts – Keep track of your bank accounts, credit cards, etc.Improved duplicate transaction checker for Moneyspire Connect and file importsĪll the tools you need to manage your finances:.Added date field shortcut keys on Windows (already supported on Mac): t – today’s date, m – beginning of month, h – end of month, y – beginning of year, r – end of year. ![]()
![]() Alfred Curie – if he actually existed – brought along because of his surname – Marie and Pierre Curie had no relation of that name. Alexis Moussali was probably the brains behind the commercial operation, with Dr. In 1933, a pharmacist, Alexis Moussali and a Parisian doctor, Alfred Curie, launched a French range of radioactive beauty products, first from the Rue des Capucines and then from 146 Avenue Victor Hugo. Fortunately, sales of Radior remained low in the United States and those individuals that did use the products were exposed to very low levels of radiation. Radior countered the misconception with a guarantee that radium was present in every product. For this reason and because of its enormous strength we are able to use it in these pads and still sell them at a profit.” (Foster, 1920, p. The radium would still be genuine and would retain all its valuable properties. It seems incredible, I know, but chemists are used to these infinitesimal divisions. The spokesperson explained that it was “possible to divide and subdivide radium until you can get as small an amount as one sixty-fourth of a cent’s worth. medicine and public disbelief that such an expensive material could be used in cosmetic pads. In an interview, a company spokesperson noted that market research put the cause for poor sales on the reduced use of radium in U.S. The product did less well in America when introduced there. A continuous steady current of energy flows into the skin, and before long the wrinkles have disappeared, the nerves have become strong and energised, and the tired muscles have become braced up and “ready for service.” If placed on the face where the skin has become wrinkled or tired the radio-active forces immediately take effect on the nerves and tissues. “Radior” Chin straps are guaranteed to contain Radio-active substance and Radium Bromide. It was also available in selected stores in some parts of the British Empire. 29) as well as Harrods, Selfridges, Whiteley’s, Marshall & Snelgroves and other outlets. The product sold well in Britain, possibly due to the fact that it was distributed by Boots “in all their five hundred and eighty-five stores” (Foster, 1920, p. Each and every ‘Radior’ Toilet Requisite contains a definite quantity of Actual Radium. This Energy has been turned into Beauty’s aid. Radium Rays vitalize and energize all living tissue. When scientists discovered Radium they hardly dreamed they had unearthed a revolutionary “Beauty Secret.” They know it now. Radiorįrom about 1917, the London-based Radior company began marketing a line of cosmetics containing radium, including a Night Cream, Rouge, Compact Powder, Vanishing Cream, Talcum Powder, Hair Tonic, Skin Soap, Face Powder in six tints (Blanche, Naturelle, Rachel, Flesh, Ochre and Brunette) and assorted pads that could be strapped to the face.Īn ever-flowing Fountain of Youth and Beauty has at last been found in the Energy Rays of Radium. England also had a number of cosmetic companies that used radium but the same cannot be said of the United States. As the original work on radium was carried out by the French scientists, Marie and Pierre Curie, it is not surprising that this was more common in France than elsewhere. CosmeticsĪ number of companies put radioactive materials into cosmetics. All of these commercial applications had a common theme that the rays given off by radium had a ‘vitalising’ effect on the human body. It was added to a wide range of commercial products including: wool for babies, water dispensers, chocolate, soda water, male supports, foundation garments, condoms, toothpaste, suppositories, cigarettes, cleaning products, boot polish, fertilisers, luminous paints and cosmetics. This led to a craze for radium-based products, and radioactivity in general, during the 1920s and 1930s. It was used to treat a wide range of ailments including hair loss, impotence, atherosclerosis, high blood pressure, rheumatism, gout, sciatica, nephritis and anaemia. Medically, radium was usually injected or taken in pills. became involved in the physical system of alpha, beta, and gamma rays and the atomic structure in the chemical system of atomic weights, emanations, and transmutations in the medical system of cancer treatments and radon spas in the commercial system of luminous watches, women’s cosmetics, and medical remedies in the artistic system of luminous paintings and middle-class American culture and in the industrial system of radium extractions, the production of luminous paint, and the beauty industry. The 1898 discovery of radium by Marie and Pierre Curie generated a great deal of scientific interest and, before long, medical and other commercial uses were found for this radioactive material. Sakurai Presents, Mythra, Nick Chavez, Nintendo, Nintendo news, Nintendo of America, Nintendo Switch, Nintendo Switch news, Nintendo Versus, October 18, October 5, Octoling Wig, Pac-Man, Pichu, Pikachu, Pixar, Pokemon, Pokemon Blog, Pokemon news, Pokemon Trainer, Pyra, Riku, Roxas, Ryu, Sealing The Keyhole, Sephiroth, Snake, Sonic, Sonic Blade, Sora, Sora Ltd., Spirit Board, Spirits, Square Enix, Squirtle, Steve, Super Smash Bros. Posted in News, Nintendo, Nintendo Switch, Pikachu, Pokemon, Video games, Videos Tagged 2021, Aerial Sweep, Alex, amiibo, ARMS, Blizzaga, Challenger Pack, Charizard, Chrom, Cloud, Cloud Strife, Cloud Version, Dearly Beloved, Dearly Beloved -Swing Version, Disney, Dive to the Heart, DLC, Doom, Doom Slayer, Downloadable content, Dream Drop Distance, ESRB, Fighters Pass, Final Fantasy, Final Fantasy VII, Final Smash, Final Smashes, Firaga, Ganondorf, Greninja, Hollow Bastion, Incineroar, Ivysaur, Jigglypuff, Judd Hat, Kairi, Kazuya, Kazuya Mishima, Keyblade, Kingdom Hearts, KINGDOM HEARTS - HD 1.5 + 2.5 ReMIX - Cloud Version, Kingdom Hearts 2, Kingdom Hearts 3, Kingdom Hearts 3D, Kingdom Hearts 3D: Dream Drop Distance, KINGDOM HEARTS HD 2.8 Final Chapter Prologue, KINGDOM HEARTS HD 2.8 Final Chapter Prologue Cloud Version, KINGDOM HEARTS III + Re Mind Cloud Version, Kirby, Lucario, Magic, Mario, Masahiro Sakurai, Melody of Memory, Mewtwo, Mickey, Mickey Mouse, Mii, Mii Brawler, Mii Fighter, Mii Gunner, Mii Swordfighter, Min Min, Minecraft, Mr. ![]() ![]() In Developer tools window, click the icon shaped as a mobile gadget to start an emulator, and choose a one of the suggested devices. ![]() Press F12 or Ctrl+Shift+I to open Developer tools, or click Settings icon -> More Tools -> Developer tools. Go to Microsoft webpage to download Windows 10 ISO file. If you are trying to download original ISO image file for Windows 10 instead of downloading the media creation tool to create installation media, you could try the trick below in Google Chrome: Go to Microsoft Website, enter the Windows 7 product key and verify the key select a language and 32-bit or 64-bit version to download. If you still want to create your own installation USB/DVD media to install Windows 7 on your computer, ensure you still have the Windows 7 25-character product key (inside the box that Windows DVD came in, on the DVD or in the confirmation email). Otherwise, you could upgrade Windows 7 to Windows 10 to get technical support from Microsoft to secure your data and OS.įor now, Microsoft still provides you the original Windows 7 ghost image ISO file for downloading. It’s highly recommend to backup your Windows 7 OS and all the critical data on that computer regularly. Based on your budgets, you could get Windows 7 Extended Security Updates (ESU) for another 3 years until Januto protect your data and OS. If you still want to use Windows 7 OS, please check how to block TCP port 445 to survive from virus like WannaCry Ransomware. After Windows 7 end of life, what should you to protect your data from cyber-attack, virus? Now, the Microsoft support for Windows 7 has ended on January 14, 2020. First, you should be aware of Windows 7 end of support, and there are something you should know. Find System Type in System Summary, you could see either 圆4-based PC or x86-based PC.Ĭan I get a ghost image for Windows 7 64-bit or 32-bit from Microsoft? And how to ghost (also called backup) Windows 7 64-bit or 32-bit installed on my computer securely. Open your Start menu, type msinfo32 in the search box, and press Enter. How to tell if your computer is 32-bit or 64-bit in Windows 7/8/10? Here is the steps: Besides, the 64-bit version of Windows handles larger random access memory (RAM, 2GB - 192GB) more effectively than a 32-bit system (1GB - 4GB). What difference between 32 bit and 64-bit operating system in Windows 7? Which is better? The 32-bit processor can only run 32-bit version of Windows while the 64-bit processor could run either the 64-bit or 32-bit versions. The terms 32 bit and 64 bit refer to the way a computer's processor (CPU) handles information. ![]() For Windows Servers, Windows Sever 2008 R2 and later are only 64-bit operating system, you could not install them on 32-bit processor computer. Generally speaking, Microsoft Windows PCs operating system, including Windows XP, Vista, 7, 8, 8.1, 10, all of them contains 32-bit (x86) version and 64-bit (圆4) version.
|
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |